European champions Liverpool are second in their Champions League group - a point behind Napoli - and Klopp's side host Genk at Anfield.
Manchester United climbed back up to second in the table after second-half goals by Anthony Martial and Jesse Lingard earned a 2-0 victory at Everton -- their first win in five games in all competitions.
Edge Southampton 2-1 to take campaign to final day of the season.
The first half of Monday's World Cup Group A match between Senegal and the Netherlands ended 0-0 at Al Thumama Stadium as the Dutch were left to rue missed chances.
Liverpool manager Juergen Klopp has a midfield conundrum and his Tottenham counterpart Mauricio Pochettino must decide whether Harry Kane is ready for action as both bosses face selection dilemmas for Saturday's Champions League final.
Should the Portugal forward triumph, he will equal the record of his great rival and five-time winner Lionel Messi of Barcelona, who is also nominated.
Liverpool are determined to end the trend of selling their best players during the close season in order to build a squad capable of consistently challenging for major honours, manager Juergen Klopp said.
London clubs' erratic start to the Premier League season improved with victories for Chelsea, Tottenham Hotspur and Arsenal on Saturday but Manchester sides continued to make the running, with City and United the top two.
Senegal showed their teeth on the opening day of qualifiers for the 2021 African Cup of Nations but other continental heavyweights struggled to find form on Wednesday.
Liverpool feel they beat any team in the world at the moment and will play without fear in the Champions League final against 12-times winners Real Madrid later this month, winger Sadio Mane has said.
Images from Premier League matches played on Wednesday.
It was not so much the maths, though Liverpool's nine-point advantage over defending champions City, with one point less over Leicester City and Chelsea, is a significant gap, especially as Juergen Klopp's side have lost one league game in 18 months.
Jose Mourinho's first Premier League game as manager of Manchester United ended in a comfortable 3-1 victory away to Bournemouth on Sunday.
This is Real Madrid's third consecutive Champions League title.
Juergen Klopp has said his Liverpool team must be prepared to play ugly football to secure Champions League qualification following the injury to productive forward Sadio Mane ahead of Wednesday's Premier League clash against Bournemouth.
Images from the FIFA World Cup match between Senegal and England on Sunday.
'Porto are a really, really good football team. We have to play at our limit 100 percent'
Images from the UEFA Champions League matches played on Tuesday
Manchester City came from behind twice to earn a 2-2 draw with Liverpool in a breathless and pulsating Premier League encounter, at Anfield, on Sunday. All four goals came in the second half.
IMAGES from the soccer matches played across European leagues on Friday.
Liverpool's Egyptian forward Mohamed Salah scored his 29th Premier League goal six minutes from time to secure a 2-1 win at Crystal Palace that took them up to provisional second spot in the table on Saturday.
Five-time European champions Liverpool are in the quarter-finals of this year's competition
Juergen Klopp's side returned to English Premier League action on Friday with a hunger and desire that suggested they have spent the close-season break chomping at the bit to get back on the field.
Following are the teams in eight groups for the 2022 FIFA World Cup, which will be held in Qatar from November 20-December 18.
Liverpool could be crowned champions of England for the first time in 30 years, on Wednesday, having turned the Premier League title race into a procession.
Liverpool held their nerve to win an astonishing penalty shoot-out 11-10 and edge out Chelsea in the English League Cup final on Sunday after a rip-roaring contest had somehow ended 0-0 after extra time at Wembley.
Vinicius Junior's second half tap-in steered Real Madrid to a 1-0 victory over Liverpool in the Champions League final on Saturday.
Sadio Mane scored twice to help Senegal fight back and shock Brazil 4-2 in a friendly in Lisbon on Tuesday.
Strict rules govern transfers, with clubs able to negotiate terms with players only if they are out of contract or once a fee has been agreed with the seller. The laws also govern indirect approaches via an intermediary.
Kevin De Bruyne had to be replaced by Gabriel Jesus in the 60th minute on Saturday following a collision with Antonio Rudiger.
Vibrant Chelsea made it a torrid few days for Liverpool as goals by Willian and Ross Barkley sealed a 2-0 victory to send them through to the FA Cup quarter-finals on Tuesday. Liverpool's 44-match unbeaten streak in the Premier League ended in stunning fashion with a 3-0 defeat at Watford on Saturday and they were rocked again at Stamford Bridge.
News of all that's transpired on and off the football field
Allowing a lead to twice slip from their grasp in their last World Cup game could come back to haunt Senegal when they face Colombia in a decisive Group H clash in Samara on Thursday.
Former Manchester United striker Andy Cole is recovering in hospital after undergoing a kidney transplant, the club said in a statement on Friday.
Daniel Sturridge has said manager Juergen Klopp has put the Liverpool squad through the "most intense" pre-season of his career with the England striker pushing himself to the limit in a bid to avoid another injury-disrupted campaign.
Jurgen Klopp has agreed a contract extension with Liverpool until 2024
ManchesterCity manager Manuel Pellegrini said he had no option but to name a much-changed team for Sunday's 4-2 Premier League defeat by Southampton with the club's Champions League semi-final clash with Real Madrid scheduled on Wednesday.
Liverpool will be given a guard of honour by City's players when the top two sides meet at the Etihad on Thursday.
With 27 wins and 82 points under their belt after only one defeat all season, red-hot Liverpool set a record-breaking pace to leave teams behind them in their wake and are six points shy of ending a 30-year wait for the top-flight title.
What makes Juergen Klopp's side such an unstoppable force?
